Advanced ENT Louisville, Central KY, and Southern Indiana

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Advanced Clinical ENT Research of Kentucky and Southern Indiana

Our Research Center was developed at our Dupont office in 2002 with a core group of seven physicians. We have now grown to include our Popular Level office and ten physicians that participate in Clinical Research. We are excited to offer our patients and referring physicians an opportunity to participating in cutting edge medical products and services for the diagnosis and management of otic, nasal and sinus disorders.


Ongoing Research Studies

There’s a science to the art of breathing free. And it begins with research.

The ECLIPSE study is researching treatment for adults with chronic rhinosinusitis with nasal polyposis. The purpose of this clinical trial is to test the safety and effectiveness of the study drug, etokimab.

The study drug (etokimab or placebo) will be given by subcutaneous injection every 4 weeks for 4 months. A placebo looks like the test medicine but contains no active ingredients (medicine). Subcutaneous injections are given just under the skin into a layer of body fat (the tummy or upper arms).

To be eligible for this study, you must:

  • Be 18 to 70 years of age
  • Have nasal polyps in both nostrils

Have at least 2 of the following symptoms:

  • Nasal blockade/obstruction
  • Nasal congestion
  • Nasal discharge (anterior/posterior nasal drip)
  • Facial pain/pressure
  • Reduction or loss of smell
  • Be a non-smoker
  • Sign the informed consent form

This is not a complete list of eligibility criteria. The study doctor will review the full criteria for this study with you.

Your participation in this study will last approximately 28 weeks and you will come to the study center for about 9 visits. If you are interested in participation, please call and schedule an appointment today and tell your doctor you’re interested in the ECLIPSE study. Lead Coordinator: Ellie Fridell (502) 893-0159 x1185.

Are you suffering from chronic rhinosinusitis?

If chronic rhinosinusitis with nasal polyps is causing loss of smell, congestion, runny nose, or facial pain/pressure, you may want to consider a clinical study for adults 18 to 65 years of age.

Ask your doctor about the TITAN study.

This study is important because it will test how well a study drug works on nasal and sinus symptoms related to chronic rhinosinusitis (persistent swelling of the nasal and sinus passages) for patients with or without nasal polyps (soft growths in the nasal passages). This study will also find out if this study drug is safe.

Who can participate in this study?

To be eligible for this study, you must be:

  • 18 to 65 years of age
  • Diagnosed with chronic rhinosinusitis with or without bilateral nasal polyps
    Able to give informed consent

This is not a complete list of eligibility criteria. The study doctor will review the full criteria for this study with you.

Your participation in this study will last about 24 weeks and will include around 8 study visits to the study center. If you are interested in participation, please call and schedule an appointment today and tell your doctor you’re interested in the TITAN study. Lead Coordinator: Jennifer Leonard (502) 893-0159 x1184

BREATHE Ifetroban for Aspirin Exacerbated Respiratory Disease

If you are an adult with symptomatic AERD, you may be eligible to take part in a clinical research study called, BREATHE.

Who can take part in the BREATHE Study?

You may be eligible to join the study if:

  • You are 18 years of age or older
  • You have been diagnosed with AERD
  • You have stable asthma
  • You have sino-nasal symptoms

You also must not:

  • Be a current smoker
  • Be pregnant or breastfeeding
  • Be using steroids >20 mg per day
  • Be taking NSAIDs
  • Have a history of a bleeding condition
  • Be using an antiplatelet agent

Screening lasts up to 3 weeks and the Treatment Period is up to 8 weeks with a follow-up periods of 2 weeks. To learn more about BREATHE Study, please speak to your doctor or contact the study team. Lead Coordinator: Jennifer Leonard (502) 893-0159 x1184

Do you have ringing in the ear?

We are currently enrolling in a tinnitus study

The purpose of this trial is to evaluate the safety and tolerability of the Investigational Product and explore its effectiveness in patients with tinnitus.
The Investigational Product is given as a single injection into the middle ear through the eardrum. It is considered “investigational” because it has not been approved by the US FDA for treating tinnitus. The trial will compare an Investigational Product injection to an injection of a placebo.

  • You may be able to join the trial if you meet these criteria:
  • You are 18 to 75 years of age
  • You have had active tinnitus in one ear and are aware of it throughout most of your day

Other criteria will apply

Your participation will last 10-12 weeks. For more information, please speak with your doctor about the Otonomy Tinnitus study. Lead Coordinator Sarah Carroll 502-893-0159 x1168

We are currently enrolling in a study to test a new therapy for oral cancer
For more information, please contact Ellie Fridell at (502) 893-0159 x1185

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