Advanced ENT Louisville, Central KY, and Southern Indiana

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Serving Louisville, Central Kentucky and Southern Indiana.

Advanced Clinical ENT Research of Kentucky and Southern Indiana

Our Research Center was developed at our Dupont office in 2002 with a core group of seven physicians. We have now grown to include our Popular Level office and ten physicians that participate in Clinical Research. We are excited to offer our patients and referring physicians an opportunity to participating in cutting edge medical products and services for the diagnosis and management of otic, nasal and sinus disorders.

Ongoing Research Studies

Does Nasal Polyps have you down?

We invite individuals ages 18 -75 years of age who have bilateral nasal polyps to see if they may qualify to take part in a new clinical research study for nasal polyps.

To find out more about the study please contact our Jennifer Leonard in our Research Center at 502-893-0159 x1184  for more information.

Do you have an itchy ear?

If you’re diagnosed with otomycosis you might be elibigle to participate in a study for miconazole ear drops.

  • Any age, males, and non-pregnant or breastfeeding females
  • Experiencing two of the three: itching, pain, and fungal debris in the ear
  • Willing to do ear drops at home and keep a study diary

Study participation lasts up to 22 days with 3 or 4 office visits.

For more information on the Itchy ear study please contact Ellie Fridell in the Research Center at 502-893-0159 x1185 for more information.

Have you been struggling with Chronic Rhinosinusitis?

Patients 18 years and older with a confirmed diagnosis of chronic rhinosinusitis may be eligible to take part in this drug-coated balloon sinuplasty study.

  • Both frontal sinuses are affected
  • Prior sinus surgery more than 30 days ago

Study participation lasts 60 days with up to 7 office visits.

To find out more about the study please contact Sarah Carroll at our Research Center at 502-893-0159 x1168 for more information.


  • Met or exceeded enrollment goals in greater than 50 trials for SAR/PAR, acute/chronic sinusitis, AOMT, AOE, tinnitus, & radiation effects.
  • Top enroller nationally in a post surgical chronic sinusitis trial
  • Top enroller nationally in trials for acute otitis media with otorrhea through tympanostomy tubes
  • Top enroller nationally in a trial for acute otitis externa
  • Top enroller for a surgical device in chronic sinusitis studies
  • 2nd highest enroller in a national trial for xerostomia
  • 2nd highest enroller in a national trial for mucositis prevention during radiation therapy
  • 2nd highest enroller in a chronic sinusitis PK surgical study
  • 2nd highest enroller in a surgical device for chronic sinusitis study
  • Top 5 enroller in a national acute bacterial sinusitis trial
  • Co-Lead Principle Investigator for a national sinus stent study
  • Lead authorship on several journal articles
  • Co-authorship on numerous journal articles

Research Mission

To conduct clinical trials in accordance with the Code of Federal Regulations and our Standard Operating Procedures with respect to Good Clinical Practice. Research is conducted in a high quality, efficient, and ethical manner to assist in the advancement of medical knowledge in our field.

Clinical Research Staff

Jennifer Leonard, MA, CCRC -
Sarah Carroll, BSN, RN, CRC -
Ellie Fridell, CCRC, MLS

Research Experience

Our physicians and clinical research coordinators have completed GCP training courses on the Protection of Human Subjects and our Clinical Research Coordinators have also completed training for the Transportation of Dangerous Goods. We have experience in Adult and Pediatric Phase I-IV clinical trials for the following indications; acute sinusitis, seasonal allergic rhinitis, nasal polyposis, xerostomia, mucositis, acute otitis media, recurrent otitis media, AOMT, AOE, chronic sinusitis, perennial allergic rhinitis, tinnitus, meniere’s disease, device studies, pharmaceutical studies, PK studies and outcomes studies.

Other Support Services include:

  • Three full-time Clinical Research Coordinators; two whom are CCRC certified
  • Allergy Department onsite
  • Audiology Department onsite
  • We are part of the AAO-HNS CHEER network
  • Computerized patient database of 500,000 patients
  • CT scanner onsite
  • Nine offices servicing Kentuckiana (seven in KY, two in IN)
  • Locked drug storage and locked refrigeration
  • EDC experience
  • Calibrated equipment
  • Centrifuge
  • EKG machine
  • PFT (Pulmonary Function Testing)
  • Rapid contract and regulatory document turnaround
  • Use central IRB's
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